Partners Pediatric Multiple Sclerosis Center

 
 

Pediatric MS Research

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RESEARCH CONDUCTED AT THE PARTNERS PEDIATRIC MS CENTER:

 

 

  • Much more research is needed to better understand the impact and causes of childhood onset demyelinating diseases. At the Partners Pediatric Multiple Sclerosis Center, we are conducting research which includes a search for genes that predispose children to MS and biological markers in the blood that can distinguish various forms of MS. We are conducting active projects to study the impact of MS on vision, childhood development and quality of life. Using clinical and MRI measures, we assess the effects of treatment on slowing the disease course in children.  

 

  • We are involved in several collaborative research studies including a Longitudinal Pediatric MS study conducted with the National Network of Pediatric MS Centers of Excellence and studies with International Pediatric MS Study Group.

You may be asked if you would like to participate in some of our research studies. Participation is not mandatory for your child's care. For more information about our research studies, or to enroll your child, please call (617) 726-2664.


Some of the questions that our research studies ask are:     

              

  1. 1. Why does MS occur in children?
  2. 2. Is MS the same in adults and children?
  3. 3. What are the best treatments for MS in children?
  4. 4. How does MS affect children's development?
  5. 5. How does MS affect mood and school performance in children?
  6. 6. Is there a blood test for MS in children?
  7. 7. Is there a gene that prediposes children to develop MS?
 
 
Below is a list of our recent publications and reviews on MS and demyelinating disorders in children: 
 
 

Use of Disease-Modifying Therapies in Pediatric MS. Simone M, Chitnis T. Curr Treat Options Neurol. 2016 Aug;18(8):36. Review. PMID: 27314428.

 

Gut microbiota in early pediatric multiple sclerosis: a case-control study. Tremlett H, Fadrosh DW, Faruqi AA, Zhu F, Hart J, Roalstad S, Graves J, Lynch S, Waubant E; US Network of Pediatric MS Centers. Eur J Neurol. 2016 Aug;23(8):1308-21. PMID: 27176462; PMCID: PMC4955679.

 

Characteristics of Children and Adolescents With Multiple Sclerosis. Belman AL, Krupp LB, Olsen CS, Rose JW, Aaen G, Benson L, Chitnis T, Gorman M, Graves J, Harris Y, Lotze T, Ness J, Rodriguez M, Tillema JM, Waubant E, Weinstock-Guttman B, Casper TC; US Network of Pediatric MS Centers. Pediatrics. 2016 Jul;138(1). PMID:27358474; PMCID: PMC4925083.

 

Dietary salt intake and time to relapse in paediatric multiple sclerosis. Nourbakhsh B, Graves J, Casper TC, Lulu S, Waldman A, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Ness J, Rubin J, Krupp L, Gorman M, Benson L, Rodriguez M, Chitnis T, Rose J, Barcellos L, Waubant E; Network of Pediatric Multiple Sclerosis Centers. J Neurol Neurosurg Psychiatry. 2016 Jun 24. [Epub ahead of print]. PMID: 27343226.

 

Acute disseminated encephalomyelitis in 228 patients: A retrospective, multicenter US study. Koelman DL, Chahin S, Mar SS, Venkatesan A, Hoganson GM, Yeshokumar AK, Barreras P, Majmudar B, Klein JP, Chitnis T, Benkeser DC, Carone M, Mateen FJ. Neurology. 2016 May 31;86(22):2085-93. PMID: 27164698.

 

Pediatric Multiple Sclerosis. Lee JY, Chitnis T. Semin Neurol. 2016 Apr;36(2):148-53. PMID: 27116721.

 

Gut microbiota composition and relapse risk in pediatric MS: A pilot study. Tremlett H, Fadrosh DW, Faruqi AA, Hart J, Roalstad S, Graves J, Lynch S, Waubant E; US Network of Pediatric MS Centers. J Neurol Sci. 2016 Apr 15;363:153-7. PMID: 27000242; PMCID: PMC4806409.

 

Cognitive and patient-reported outcomes in adults with pediatric-onset multiple sclerosis. Baruch NF, O'Donnell EH, Glanz BI, Benedict RH, Musallam AJ, Healy BC, Rintell D, Chitnis T. Mult Scler. 2016 Mar;22(3):354-61. PMID: 26041802.

 

A case-control study of dietary salt intake in pediatric-onset multiple sclerosis. McDonald J, Graves J, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Lulu S, Ness J, Harris Y, Rubin J, Candee M, Krupp LB, Gorman M, Benson L, Rodriguez M, Chitnis T, Mar S, Barcellos LF, Laraia B, Rose J, Roalstad S, Simmons T, Casper TC, Waubant E. Mult Scler Relat Disord. 2016 Mar;6:87-92. PMID: 27063630; PMCID: PMC4830915.

 

Clinical and MRI phenotype of children with MOG antibodies. Fernandez-Carbonell C, Vargas-Lowy D, Musallam A, Healy B, McLaughlin K, Wucherpfennig KW, Chitnis T. Mult Scler. 2016 Feb;22(2):174-84. PMID: 26041801.

 

Clinical Features of neuromyelitis optica in children: US Network of Pediatric MS Centers report. Chitnis T, Ness J, Krupp L, Waubant E, Hunt T, Olsen CS, Rodriguez M, Lotze T, Gorman M, Benson L, Belman A, Weinstock-Guttman B, Aaen G, Graves J, Patterson M, Rose JW, Casper TC. Neurology. 2016 Jan 19;86(3)245-52. PMID: 26683648.

 

The US Network of Pediatric Multiple Sclerosis Centers: Development, Progress, and Next Steps. Casper TC, Rose JW, Roalstad S, Waubant E, Aaen G, Belman A, Chitnis T, Gorman M, Krupp L, Lotze T, Ness J, Patterson M, Rodriguez M, Weinstock-Huttman B, Browning B, Graves J, Tilema JM, Benson L, Harris Y; the US Networkm of Pediatric Multiple Sclerosis Centers. J Child Neurol. 2015 Sep;30(10):1387-7. PMID: 25270659.

 

International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Caroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A, Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG. Neurology. 2015 Jul 14;85(2):177-89. Review. PMID: 26092914.


Demographic and clinical features of neuromyelitis optica: A review. Pandit L, Asgari N, Apiwattanakul M, Palace J, Paul F, Leite MI, Kleiter I, Chitnis T; GJCF International Clinical Consortium & Biorepository for Neuromyelitis Optica. Mult Scler. 2015 Jun;21(7):845-53. Review. PMID: 25921037, PMCID: PMC4463026.

 

Impact of MS during the critical window of brain development. Chitnis T, Gorman MP. Neurology. 2014 Dec 2;83(23):2106-7. PMID: 25378681.

 

Protective environmental factors for neuromyelitis optica. Graves J, Grandhe S, Weinfurtner K, Krupp L, Belman A, Chitnis T, Ness J, Weinstock-Guttman B, Gorman M, Patterson M, Rodriguez M, Lotze T, Aaen G, Mowry EM, Rose JW, Simmons T, Casper TC, James J, Waubant E; US Network of Pediatric Multiple Sclerosis Centers. Neurology. 2014 Nov 18;83(21):1923-9. PMID: 25339213; PMCID: PMC4248458.

 

Functional relapses in pediatric multiple sclerosis. Fernández Carbonell C, Benson L, Rintell D, Prince J, Chitnis T. J Child Neurol. 2014 Jul;29(7):943-6. PMID: 24065582.

 

B-cell depletion in children with neuroimmunologic conditions: the learning curve. Chitnis T, Waubant E. Neurology. 2014 Jul 8;83(2):111-2. PMID: 24920852.

Longitudinal evaluation of cognitive functioning in pediatric multiple sclerosis: report from the US Pediatric Multiple Sclerosis Network. Charvet L, O'Donnell E, Belman A, Chitnis T, Ness J, Parrish J, Patterson M, Rodriguez M, Waubant E, Weinstock-Guttman B, Krupp L; on behalf of the US Network of Pediatric MS Centers. Mult Scler. 2014 Mar 31. PMID: 24687807.

Elevated relapse rates in pediatric compared to adult MS persist for at least 6 years. Benson LA, Healy BC, Gorman MP, Baruch NF, Gholipour T, Musallam A, Chitnis T. Mult Sler Relat Disord. 2014 Mar;3(2):186-93. PMID: 25878006.

Balo Concentric Sclerosis in Children: A Case Series. Linnoila J, Chitnis T. J Child Neurol. 2014 Jan 14. PMID: 24423690.

 

Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing-remitting multiple sclerosis. Van Haren K, Tomooka BH, Kidd BA, Banwell B, Bar-Or A, Chitnis T, Tenembaum SN, Pohl D, Rostasy K, Dale RC, O'Connor KC, Hafler DA, Steinman L, Robinson WH. Mult Scler. 2013 Nov;19(13):1726-33. PMID: 23612879; PMCID: PMC4411183.


Role of puberty in multiple sclerosis risk and course. Chitnis T. Clin Immunol. 2013 Nov;149(2):192-200. PMID: 23623473

 
Quantitative MRI analysis in children with multiple sclerosis: a multicenter feasibility pilot study. Chitnis T, Guttmann CR, Zaitsev A, Musallam A, Weinstock-Guttmann B, Yeh A, Rodriguez M, Ness J, Gorman M, Healy BC, Kuntz N, Chabas D, Strober JB, Waubant E, Krupp L, Pelletier D, Erickson B, Bergsland N, Zivadinov R. BMC Neurol. 2013 Nov 13;13(1):173. PMID:24225378; PMCID: PMC3832402.


International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions. Krupp LB, Tardieu M, Amato MP, Banwell B, Chitnis T, Dale RC, Ghezzi A, Hintzen R, Kornberg A, Pohl D, Rostasy K, Tenembaum S, Wassmer E; the International Pediatric Multiple Sclerosis Study Group. Mult Scler. 2013 Sept;19(10):1261-7. PMID: 23572237

 
Paediatric MS is the same disease as adult MS: no. Chitnis T. Mult Scler. 2013 Sep;19(10):1255-6. PMID: 23996596.

Pediatric demyelinating diseases. Chitnis T. Continuum. 2013 Aug;19(4 Multiple Sclerosis):1023-45. PMID: 23917099.

 

Antibody response to common viruses and human leukocyte antigen-DRB1 in pediatric multiple sclerosis. Waubant E, Mowry EM, Krupp L, Chitnis T, Yeh EA, Kuntz N, Ness J, Belman A, Milazzo M, Gorman M, Weinstock-Guttman B, Rodriguez M, James IA. Mult Sclero. 2013 Jun;19(7):891-5. PMCID: PMC23232601 


Inflammatory demyelinating diseases in children: an update. Fernandez Carbonell C, Chitnis T. Minerva Pediatr. 2013 Jun;65(3):307-23. PMID: 23685382


International Pediatric MS Study Group Clinical Trials Summit: meeting report. Chitnis T, Tardieu M, Amato MP, Banwell B, Bar-Or A, Ghezzi A, Kornberg A, Krupp LB, Pohl D, Rostasy K, Tenembaum S, Waubant E, Wassmer E. Neurology. 2013 Mar 19;80(12):1161-8. PMID: 23509048


Increased Th17 response to myelin peptides in pediatric MS. Vargas-Lowy D, Kivisakk P, Gandhi R, Raddassi K, Soltany P, Gorman MP, Khoury SJ, Chitnis T. Clin Immunol. 2013 Mar;146(3):176-84. PMID: 23352968   


Cognitive impairment occurs in children and adolescents with multiple sclerosis: results from a United States network. Julian L, Serafin D, Charvet L, Ackerson J, Benedict R, Braaten E, Brown T, O'Donnell E, Parrish J, Preston T, Zaccariello M, Belman A, Chitnis T, Gorman M, Ness J, Patterson M, Rodriguez M, Waubant E, Weinstock-Guttman B, Yeh A, Krupp LB; Network of Pediatric MS Centers of Excellence. J Child Neurol. 2013 Jan;28(1):102-7. PMID: 23155206

Diffusion tensor analysis of pediatric multiple sclerosis. Vishwas MS, Healy BC, Pienaar R, Gorman MP, Grant PE, Chitnis T. AJNR Am J Neuroradiol. 2013 Feb; 34(2):417-23. PMID: 22859275


Disease-modifying therapy of pediatric multiple sclerosis. Chitnis T. Neurotherapeutics. 2013 Jan;10(1):89-96. PMCID: PMC23224690


Cognitive impairment occurs in children and adolescents with multiple sclerosis: results from a United States network. Julian L, Serafin D, Charvet L, Ackerson J, Benedict R, Braaten E, Brown T, O’Donnell E, Parrish J, Preston T, Zaccariello M, Belman A, Chitnis T, Gorman M, Ness J, Patterson M, Rodriguez M, Waubant E, Weinstock-Guttman B, Yeh A, Krupp LB; Network of Pediatric MS Centers of Excellence. J Child Neurol. 2013 Jan;28(1):102-107. PMCID: PMC23155206


Pathogenesis of pediatric multiple sclerosis. Wargas-Lowy D, Chitnis T. J Child Neurol. 2012 Nov;27(11):1394-407. PMCID: PMC22952316


Diffusion tensor analysis of pediatric multiple sclerosis and clinically isolated syndromes. Vishwas MS, Healy BC, Pienaar R, Gorman MP, Grant PE, Chitnis T. ANJR Am J Neuroadiol. 2012 Aug 2. PMCID: PMC22859275

 

Consensus statement: evaluation of new and existing therapeutics for pediatric multiple sclerosis. Chitnis T, Tenembaum S, Banwell B, Krupp L, Pohl D, Rostasy K, Yeh EA, Bykova O, Wassmer E, Tardieu M, Kornberg A, Ghezzi A; International Pediatric Multiple Sclerosis Study Group. Mult Scler. 2012 Jan;18(1):116-27. PMID: 22146610.


Daclizumab use in patients with pediatric multiple sclerosis.  Gorman MP, Tillema JM, Ciliax AM, Guttmann CR, Chitnis T. Arch Neurol. 2012 Jan;69(1):78-81. PMID: 22232346


Gestational vitamin D and the risk of multiple sclerosis in offspring. Mirzaei F, Michels KB, Munger K, O'Reilly E, Chitnis T, Forman MR, Giovannucci E, Rosner B, Ascherio A. Ann Neurol. 2011 Jul;70(1):30-40. PMID: 21786297


Common viruses associated with lower pediatric multiple sclerosis risk. Waubant E, Mowry EM, Krupp L, Chitnis T, Yeh EA, Kuntz N, Ness J, Chabas D, Strober J, McDonald J, Belman A, Milazzo M, Gorman M, Weinstock-Guttman B, Rodriguez M, Oksenberg JR, James JA; US Pediatric MS Network. Neurology. 2011 Jun 7;76(23):1989-95. PMID: 21646624; PMCID: PMC3109881.


Pediatric multiple sclerosis. Chitnis T, Krupp L, Yeh A, Rubin J, Kuntz N, Strober JB, Chabas D, Weinstock-Guttmann B, Ness J, Rodriguez M, Waubant E. Neurol Clin. 2011 May;29(2):481-505. PMID: 21439455.


Multiple sclerosis therapies in pediatric patients with refractory multiple sclerosis. Yeh EA, Waubant E, Krupp LB, Ness J, Chitnis T, Kuntz N, Ramanathan M, Belman A, Chabas D, Gorman MP, Rodriguez M, Rinker JR 2nd, Weinstock-Guttman B; National Network of Pediatric MS Centers of Excellence. Arch Neurol. 2011 Apr;68(4):437-44. PMID: 21149803


Treatment of multiple sclerosis in children and adolescents. Kuntz NL, Chabas D, Weinstock-Guttman B, Chitnis T, Yeh EA, Krupp L, Ness J, Rodriguez M, Waubant E; Network of US Pediatric Multiple Sclerosis Centers. Expert Opin Pharmacother. 2010 Mar;11(4):505-20. Review. PMID: 20163265. 


Younger children with MS have a distinct CSF inflammatory profile at disease onset.  Chabas D, Ness J, Belman A, Yeh EA, Kuntz N, Gorman MP, Strober JB, De Kouchkovsky I, McCulloch C, Chitnis T, Rodriguez M, Weinstock-Guttman B, Krupp LB, Waubant E; US Network of Pediatric MS Centers of Excellence. Neurology. 2010 Feb 2;74(5):399-405. PMID: 20124205; PMCID: PMC2816008.


Tract Based Analysis of callosal Projection and Association Pathways in Pediatric Patients with Multiple Sclerosis. Vishwas M, Chitnis T, Pienaar R, Healy BC, Grant PE. AJNR. Am J Neuroradiol. 2010 Jan;31(1):121-8. PMID: 19850763


Prenatal and perinatal factors and risk of MS.  Gardner H, Munger KL, Chitnis T, Michels, KB, Spiegelman D, Ascherio A. Epidemiology. 2009 Jul;20(4):611-8. PMID: 19333127.


Demographics of Pediatric-onset Multiple Sclerosis in an MS Center population from the Northeastern United States. Chitnis T, Glanz B, Jaffin S, Healy BC. Mult Scler. 2009 May;15(5):627-31. PMID: 19299440.


Cyclophosphamide therapy in pediatric multiple sclerosis.  Makhani N, Gorman MP, Branson H, Stazzone L, Banwell B, Chitnis T. Neurology. 2009 Jun 16;72(24):2076-82. PMID: 19439723; PMCID: PMC2923592.


Sensitivity vs. specificity: progress and pitfalls in defining MRI criteria for Pediatric MS. Chitnis T, Pirko I. (2009) Sensitivity versus Specificity: Neurology. Editorial, 2009 Mar 17;72(11):952-3. PMID: 19289735


Increased relapse rate in pediatric compared to adult-onset multiple sclerosis. Gorman MP, Healy BC, Polgar-Turcsanyi M, Chitnis T. Arch Neurol. 2009 Jan;66(1):54-9. PMID: 19139299.

 

T cell based Therapies in Multiple Sclerosis in Multiple Sclerosis Therapeutics. Chitnis T, Khoury SJ (2007) Eds. Cohen J and Rudick R.  3rd Edition. Chapter.  


Acute disseminated encephalomyelitis. Tenembaum S, Chitnis T, Ness J, Hahn JS; International Pediatric MS Study Group. Neurology. 2007 Apr 17;68(16 Suppl 2):S23-36. Review. PMID: 17438235.

 

Challenges in the classification of pediatric multiple sclerosis and future directions. Belman AL, Chitnis T, Renoux C, Waubant E; International Pediatric MS Study Group. Neurology. 2007 Apr 17;68(16 Suppl 2):S70-4. Review. PMID: 17438242.


Treatment of pediatric multiple sclerosis and variants. Pohl D, Waubant E, Banwell B, Chabas D, Chitnis T, Weinstock-Guttman B, Tenembaum S. International Pediatric MS Study Group. Neurology. 2007 Apr 17;68(16 Suppl 2):S54-65. Review. PMID: 17438239.


Self-antigen tetramers discriminate between myelin autoantibodies to native or denature protein. O’Connor KC, McLaughlin KA, DeJager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Tenmbaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta, V, Rostasy K, Pohl D, Dale RC, Freedman, M, Steinman L, Khoury SJ, Weiner HL, Kuchroo VK, Hafler DA, Wucherpfennig K. Nat. Med. Feb;13(2):211-7. PMID: 17237795; PMCID: PMC3429369.


Pediatric Multiple Sclerosis. Chitnis T. Neurologist. Nov;12(6):299-310. Review. PMID: 17122726.


 

 

 

 

 













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