Pediatric MS Research
RESEARCH CONDUCTED AT THE PARTNERS PEDIATRIC MS CENTER:
- Much more research is needed to better understand the impact and causes of childhood onset demyelinating diseases. At the Partners Pediatric Multiple Sclerosis Center, we are conducting research which includes a search for genes that predispose children to MS and biological markers in the blood that can distinguish various forms of MS. We are conducting active projects to study the impact of MS on vision, childhood development and quality of life. Using clinical and MRI measures, we assess the effects of treatment on slowing the disease course in children.
- We are involved in several collaborative research studies including a Longitudinal Pediatric MS study conducted with the National Network of Pediatric MS Centers of Excellence and studies with International Pediatric MS Study Group.
You may be asked if you would like to participate in some of our research studies. Participation is not mandatory for your child's care. For more information about our research studies, or to enroll your child, please call (617) 726-2664.
Some of the questions that our research studies ask are:
- 1. Why does MS occur in children?
- 2. Is MS the same in adults and children?
- 3. What are the best treatments for MS in children?
- 4. How does MS affect children's development?
- 5. How does MS affect mood and school performance in children?
- 6. Is there a blood test for MS in children?
- 7. Is there a gene that prediposes children to develop MS?
Below is a list of our recent publications and reviews on MS and demyelinating disorders in children:
Pediatric demyelinating diseases. Chitnis T. Continuum. 2013 Aug;19(4 Multiple Sclerosis):1023-45. PMID: 23917099
Serum antibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing-remitting multiple sclerosis. Van Haren K, Tomooka BH, Kidd BA, Banwell B, Bar-Or A, Chitnis T, Tenembaum SN, Pohl D, Rostasy K, Dale RC, O'Connor KC, Hafler DA, Steinman L, Robinson WH. Mult Scler. 2013 Apr 23. [Epub ahead of print] PMID: 23612879
International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions. Krupp LB, Tardieu M, Amato MP, Banwell B, Chitnis T, Dale RC, Ghezzi A, Hintzen R, Kornberg A, Pohl D, Rostasy K, Tenembaum S, Wassmer E; the International Pediatric Multiple Sclerosis Study Group. Mult Scler. 2013 Apr 9. [Epub ahead of print] PMID: 23572237
International Pediatric MS Study Group Clinical Trials Summit: meeting report. Chitnis T, Tardieu M, Amato MP, Banwell B, Bar-Or A, Ghezzi A, Kornberg A, Krupp LB, Pohl D, Rostasy K, Tenembaum S, Waubant E, Wassmer E. Neurology. 2013 Mar 19;80(12):1161-8. PMID: 23509048
Cognitive impairment occurs in children and adolescents with multiple sclerosis: results from a United States network. Julian L, Serafin D, Charvet L, Ackerson J, Benedict R, Braaten E, Brown T, O'Donnell E, Parrish J, Preston T, Zaccariello M, Belman A, Chitnis T, Gorman M, Ness J, Patterson M, Rodriguez M, Waubant E, Weinstock-Guttman B, Yeh A, Krupp LB; Network of Pediatric MS Centers of Excellence. J Child Neurol. 2013 Jan;28(1):102-7. Epub 2012 Nov 15. PMID: 23155206
Diffusion tensor analysis of pediatric multiple sclerosis. Vishwas MS, Healy BC, Pienaar R, Gorman MP, Grant PE, Chitnis T. AJNR Am J Neuroradiol. 2013 Feb; 34(2):417-23. Epub 2012 Aug 2. PMID: 22859275
Antibody response to common
viruses and human leukocyte antigen-DRB1 in pediatric multiple sclerosis.
Waubant E, Mowry EM, Krupp L, Chitnis T, Yeh EA, Kuntz N, Ness J, Belman A,
Milazzo M, Gorman M, Weinstock-Guttman B, Rodriguez M, James IA. Mult Sclero.
2012 Dec 11. PMCID: PMC23232601
Cognitive impairment occurs
in children and adolescents with multiple sclerosis: results from a United
States network. Julian L, Serafin D, Charvet L, Ackerson J, Benedict R,
Braaten E, Brown T, O’Donnell E, Parrish J, Preston T, Zaccariello M, Belman A,
Chitnis T, Gorman M, Ness J, Patterson M, Rodriguez M, Waubant E,
Weinstock-Guttman B, Yeh A, Krupp LB; Network of Pediatric MS Centers of
Excellence. J Child Neurol. 2013 Jan;28(1):102-107. Epub 2012 Nov 15. PMCID:
Pathogenesis of pediatric
multiple sclerosis. Wargas-Lowy D, Chitnis T. J Child Neurol. 2012
Nov;27(11):1394-407. Epub 2012 Sep 5. PMCID: PMC22952316
Diffusion tensor analysis of
pediatric multiple sclerosis and clinically isolated syndromes. Vishwas MS,
Healy BC, Pienaar R, Gorman MP, Grant PE, Chitnis T. ANJR Am J Neuroadiol. 2012
Aug 2. PMCID: PMC22859275
of new and existing therapeutics for pediatric MS. Chitnis T, S. Tenembaum,
B. Banwell, L. Krupp, D. Pohl, K. Rostasy, E.A. Yeh, O. Bykova, E. Wassmer, M.
Tardieu, A. Kornberg, A. Ghezzi and for the International Pediatric MS Study
Group.. Multiple Sclerosis. 2012 Jan;18(1):116-27. Epub 2011 Dec 6. PMCID: PMD 22146610
Daclizumab use in patients
with pediatric multiple sclerosis. Gorman MP, Tillema JM, Ciliax AM,
Guttmann CR, Chitnis T. Arch Neurol. 2012 Jan;69(1):78-81.
statement: evaluation of new and existing therapeutics for pediatric multiple
Chitnis T, Tenembaum S, Banwell B, Krupp L, Pohl D, Rostasy K, Yeh E,
Bykova O, Wassmer E, Tardieu M, Kornberg A, Ghezzi A. Mult Scler. 2011 Dec 6.
Common viruses associated
with lower pediatric multiple sclerosis risk. Waubant E, Mowry EM, Krupp L, Chitnis T, Yeh EA, Kuntz N, Ness J, Chabas
D, Strober J, McDonald J, Belman A, Milazzo M, Gorman M, Weinstock-Guttman B,
Rodriguez M, Oksenberg JR, James JA; US Pediatric MS Network. Neurology. 2011
multiple sclerosis. Chitnis T, Krupp L, Yeh A, Rubin J, Kuntz N,
Strober JB, Chabas D, Weinstock-Guttmann B, Ness J, Rodriguez M, Waubant E.
Neurol Clin. 2011 May;29(2):481-505.
Multiple sclerosis therapies
in pediatric patients with refractory multiple sclerosis.
Yeh EA, Waubant E, Krupp LB, Ness J, Chitnis T, Kuntz N, Ramanathan M, Belman
A, Chabas D, Gorman MP, Rodriguez M, Rinker JR 2nd, Weinstock-Guttman B;
National Network of Pediatric MS Centers of Excellence. Arch Neurol. 2011
Apr;68(4):437-44. Epub 2010 Dec 13. PMCID: PMD 21149803
Treatment of multiple
sclerosis in children and adolescents. Kuntz NL, Chabas D, Weinstock-Guttman B,
Chitnis T, Yeh EA, Krupp L, Ness J, Rodriguez M, Waubant E; Network of US
Pediatric Multiple Sclerosis Centers. Expert Opin Pharmacother. 2010
Mar;11(4):505-20. Review. PMCID: PMD 20163265
Younger children with MS
have a distinct CSF inflammatory profile at disease onset. Chabas D, Ness J, Belman A, Yeh EA, Kuntz N,
Gorman MP, Strober JB, De Kouchkovsky I, McCulloch C, Chitnis T, Rodriguez M,
Weinstock-Guttman B, Krupp LB, Waubant E; US Network of Pediatric MS Centers of
Excellence. Neurology. 2010 Feb 2;74(5):399-405. PMCID: PMD 20124205
Tract Based Analysis of
callosal Projection and Association Pathways in Pediatric Patients with
Multiple Sclerosis. Vishwas M, Chitnis T, Pienaar R, Healy BC, Grant PE.
AJNR. Am J Neuroradiol. 2010 Jan;31(1):121-8. PMCID: PMD 19850763
and perinatal factors and risk of MS. Gardner H, Munger KL, Chitnis
T, Michels, KB, Spiegelman D, Ascherio A. Epidemiology. (2009)
Jul;20(4):611-8 PMCID: PMD 19333127
of Pediatric-onset Multiple Sclerosis in an MS Center population from the
Northeastern United States. Chitnis T,
Glanz B, Jaffin S, Healy BC. Mult Scler. 2009 May;15(5):627-31. Epub 2009 Mar PMCID: PMD19299440
Cyclophosphamide therapy in
pediatric multiple sclerosis. Makhani N, Gorman MP, Branson H,
Stazzone L, Banwell B, Chitnis T. (2009) Neurology. ePub May 13.
vs. specificity: progress and pitfalls in defining MRI criteria for Pediatric
MS. Chitnis T, Pirko I. (2009) Sensitivity versus Specificity:
Neurology. (2009) Editorial, Mar 17;72(11):952-3. PMCID: PMD19289735
Increased relapse rate in
pediatric compared to adult-onset multiple sclerosis. Gorman MP, Healy BC,
Polgar-Turcsanyi M, Chitnis T. Arch Neurol. 2009 Jan;66(1):54-9. PMCID:
Disseminated Encephalomyelitis; in Inflammatory and autoimmune disorders of the
nervous system in children. Tenembaum S, Chitnis T. (2008) Eds. Russell
RC, Vincent A. Chapter. In press.
of pediatric multiple sclerosis and variants. Pohl D, Waubant E, Banwell B,
Chabas D, Chitnis T, Weinstock-Guttman B, Tenembaum S. (2007)
International Pediatric MS Study Group. (2007) Neurology. 68(16 Suppl
tetramers discriminate between myelin autoantibodies to native or denature
protein. O’Connor KC, McLaughlin KA, DeJager PL, Chitnis T,
Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H,
Tenmbaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta, V, Rostasy K, Pohl D,
Dale RC, Freedman, M, Steinman L, Khoury SJ, Weiner HL, Kuchroo VK, Hafler DA,
Wucherpfennig K. (2007) Nat. Med. Feb;13(2):211-7.
Multiple Sclerosis. Chitnis T (2006) The
Neurologist. Nov;12(6):299-310. Review.